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. Author manuscript; available in PMC: 2023 Aug 18.
Published in final edited form as: Cell Chem Biol. 2022 Jul 12;29(8):1303–1316.e3. doi: 10.1016/j.chembiol.2022.06.006

Figure 1: Structure-guided design of allosteric Hsp70 inhibitor MKT-077 analogs.

Figure 1:

(A) Medicinal chemistry campaign led to more potent molecules against breast cancer cells; (B) Anti-cancer activities of benchmarked molecules. Anti-proliferative activity by 72h MTT assay and the data given are mean values derived from at least two independent replicates.