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| Uncontrolled, inadequately treated asthma |
| Augmentation factors such as physical exertion |
| Current allergic symptoms |
| Acute infections |
| Mast cell disease and elevated tryptase |
| High degree of sensitization of the patient |
| Previous anaphylactic reactions during AIT |
| Inadequate dose escalation during initiation therapy and dosing errors in general |
| Unsuitable injection technique (for SCIT) |
