Table 7. Criteria for examining the individual suitability of patients for the respective AIT application route, modified from [33].

	Pros	Cons
Subcutaneous route	Application by doctor = certainty about administration	Regular visits to the doctor (time-consuming)
	Frequent doctor-patient contact > regular monitoring of the course of the AIT, side effects, and underlying disease(s) of the patients possible	Possible fear of injections
		At least 30 minutes of post-injection monitoring time
		Risk of systemic allergic reactions (very rare)
		Risk of local side effects (frequent)
Sublingual route	Non-painful procedure	Risk of local side effects (very frequent, mostly mild and self-limiting)
	Can be carried out at home (usually first application at the doctor’s office with 30-minute monitoring)	Usually daily application necessary over a longer period of time (pre-/co-seasonal, i.e., several months, or perennial > daily “remembering”)
	Visits to the doctor’s office rarely necessary	Mucosal contact for 2 minutes and motivation of the patients necessary (check especially with children)
	Very low risk of systemic reactions (lower than with SCIT)