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Impact of efflux inhibition using elacridar in TKO mice. Data represent mean ± S.D. (n = 4). *P < 0.05. (A) Plasma, brain and spinal cord concentrations; (B) Kpbrain and Kp spinal cord; and (C) Kpuu,brain and Kpuu,spinal cord at 2 hours after coadministration of 10 mg/kg oral AZD1390 and 10 mg/kg intraperitoneal elacridar in TKO mice.
