TABLE 2.

Summary of pharmacokinetic parameters in plasma, brain, and spinal cord in FVB wild-type and TKO mice after a single oral dose of 10 mg/kg AZD1390

Parameter	Units	Plasma		Brain		Spinal Cord
		Wild-Type	Mdr1a/b−/− Bcrp1−/−	Wild-Type	Mdr1a/b−/− Bcrp1−/−	Wild-Type	Mdr1a/b−/− Bcrp1−/−
Tmax	hour	1	0.5	2	2	2	2
Cmax	ng/ml	1523 ± 435	1367 ± 207	215 ± 11	3925 ± 599	104 ± 14	2491 ± 404
t 1/2	hour	3.4	3.3	3.4	2.8	3.9	2.8
CL/F	l/hr/kg	2.2	1.9
Vd/F	l/kg	10.7	9.0
AUC0-∞	hr*ng/ml	4543 ± 538	5313 ± 795	1440 ± 131	19,783 ± 1378	1057 ± 224	13,410 ± 967
Oral Bioavailability		0.43	0.48
Kp				0.32	3.72	0.23	2.52
Kpuu				0.12	1.37	0.12	1.37
DAfree			1	11.4	1	11.4

T_max, time to reach C_max.