Table 2.
Mean values of DTI parameters for the TBWM and WML segmentation for RRMS patients compared to HCs. MD, RD and AD are in 10−13 mm 2 /s, except FA which is unitless.
| Regions | DTI measure | HCs | RRMS | Difference % | p-value |
|---|---|---|---|---|---|
| Sample size | — | N = 19 | N = 37 | — | — |
| TBWM | MD | 0.527 ± 3.E−03 | 0.546 ± 3.E−03 | 3.6 | 9.E−05 |
| — | RD | 0.421 ± 4.E−03 | 0.441 ± 3.E−03 | 4.8 | 1.E−04 |
| — | AD | 0.739 ± 4.E−03 | 0.755 ± 4.E−03 | 2.7 | 7.E − 03 |
| — | FA | 0.356 ± 4.E−03 | 0.340 ± 3.E−03 | −4.3 | 5.E − 03 |
| WML | MD | 0.410 ± 4.E−03 | 0.471 ± 9.E−03 | 12.2 | 4.E − 05 |
| — | RD | 0.343 ± 5.E−03 | 0.397 ± 9.E−03 | 13.1 | 8.E − 05 |
| — | AD | 0.573 ± 5.E−03 | 0.610 ± 9.E−03 | 7.4 | 3.E − 03 |
| — | FA | 0.270 ± 6.E−03 | 0.231 ± 5.E−03 | −16.9 | 3.E − 05 |
Values are expressed in mean ± standard error of measurement.
HCs: healthy controls; RRMS: relapse-remitting multiple sclerosis; MD: mean diffusivity; RD: radial diffusivity; AD: axial diffusivity; FA: fractional anisotropy; TBWM: total brain white matter; WML: white matter lesion.