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. 2021 Sep 16;178(Suppl 1):S246–S263. doi: 10.1111/bph.15540
Nomenclature Androgen receptor Glucocorticoid receptor
Systematic nomenclature NR3C4 NR3C1
HGNC, UniProt AR , P10275 NR3C1 , P04150
Rank order of potency dihydrotestosterone > testosterone cortisol, corticosteronealdosterone, deoxycortisone [123]
Endogenous agonists dihydrotestosterone [142]
Selective agonists testosterone propionate [93], mibolerone [50], fluoxymesterone [60], methyltrienolone [148], dromostanolone propionate fluticasone propionate [10], flunisolide [3], beclometasone [3], methylprednisolone [3], betamethasone [3], budesonide [100]
Selective antagonists bicalutamide (pKi 7.7) [69], PF0998425 (pIC50 7.1–7.5) [84], enzalutamide (pIC50 7.4) [143], nilutamide (pIC50 7.1–7.1) [131], hydroxyflutamide (pEC50 6.6) [148], galeterone (pIC50 6.4) [56], flutamide (Displacement of 3[H] testosterone from wild‐type androgen receptors) (pKi 5.4) [147] onapristone (pIC50 7.6) [165], ZK112993
Labelled ligands [3H]dihydrotestosterone (Selective Agonist), [3H]methyltrienolone (Selective Agonist), [3H]mibolerone (Agonist) [3H]dexamethasone (Agonist)