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. 2022 Sep 27;167(12):2677–2688. doi: 10.1007/s00705-022-05612-6

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Composition and substitution analysis of SARS-CoV-2 isolated from animals. (A) The reported animals infected with SARS-CoV-2 with the defined transmission route from humans to animals. (B) Phylogenetic tree constructed by the maximum-likelihood method with the Tamura-Nei model in MEGA X with 500 bootstrap replicates. Red dots represent human sequences from infected animals, and blue dots represent sequences from infected white-tailed deer. (C) The proportions of uracil, guanine, thymine, and cytidine substitutions (nonsynonymous) in SARS-CoV-2 isolated from human or animals. (D) Base pair changes observed in the SARS-CoV-2 genomes. All of the transitions and transversions are listed in Supplementary Table S2. (E) The synonymous and nonsynonymous substitutions in mink SARS-Cov-2. (F) The relative proportion of each nucleotide substitution in the mink SARS-CoV-2 genome.