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. 2022 Sep 27:1–17. Online ahead of print. doi: 10.1007/s10238-022-00890-5

Table 1.

List of the top 100 most cited articles in anaphylaxis(1991-2021)

Rank Article Total Number of Citations Average Citations per Year Length of Time since Publication IF
1 Sampson H A, Mendelson L, Rosen J P. Fatal and near-fatal anaphylactic reactions to food in children and adolescents[J]. New England Journal of Medicine, 1992, 327(6): 380–384 1243 41.43 30 91.253
2 Bock S A, Muñoz-Furlong A, Sampson H A. Fatalities due to anaphylactic reactions to foods[J]. Journal of Allergy and Clinical Immunology, 2001, 107(1): 191–193 1173 55.86 21 10.793
3 Chung C H, Mirakhur B, Chan E, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1, 3-galactose[J]. New England journal of medicine, 2008, 358(11): 1109–1117 921 65.79 14 91.253
4 Pumphrey R S H. Lessons for management of anaphylaxis from a study of fatal reactions[J]. Clinical and experimental allergy, 2000, 30(8): 1144–1150 693 31.50 22 5.018
5 Brown S G A. Clinical features and severity grading of anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 2004, 114(2): 371–376 548 30.44 18 10.793
6 Muraro A, Roberts G, Worm M, et al. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology[J]. Allergy, 2014, 69(8): 1026–1045 545 68.13 8 13.146
7 Simons F E R, Ardusso L R F, Bilò M B, et al. World allergy organization guidelines for the assessment and management of anaphylaxis[J]. World Allergy Organization Journal, 2011, 4(2): 13–37 453 41.18 11 4.084
8 Nelson H S, Lahr J, Rule R, et al. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract[J]. Journal of Allergy and Clinical Immunology, 1997, 99(6): 744–751 431 17.24 25 10.793
9 Lieberman P, Nicklas R A, Oppenheimer J, et al. The diagnosis and management of anaphylaxis practice parameter: 2010 update[J]. Journal of Allergy and Clinical immunology, 2010, 126(3): 477–480 401 33.42 12 10.793
10 Commins S P, Satinover S M, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1, 3-galactose[J]. Journal of Allergy and Clinical Immunology, 2009, 123(2): 426–433 388 29.85 13 10.793
11 Sampson H A. Anaphylaxis and emergency treatment[J]. Pediatrics, 2003, 111(Supplement 3): 1601–1608 367 19.32 19 7.125
12* Muraro A, Roberts G, Clark A, et al. The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology[J]. Allergy, 2007, 62(8): 857–871 365 24.33 15 13.146
13 Mertes P M, Laxenaire M C, Alla F. Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999–2000.[J]. Anesthesiology, 2003, 99(3):536 365 19.21 19 7.892
14 Yocum M W, Butterfield J H, Klein J S, et al. Epidemiology of anaphylaxis in Olmsted County: a population-based study[J]. Journal of Allergy and Clinical Immunology, 1999, 104(2): 452–456 354 15.39 23 10.793
15 Vadas P, Gold M, Perelman B, et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis[J]. New England Journal of Medicine, 2008, 358(1): 28–35 346 24.71 14 91.253
16 Turner P J, Gowland M H, Sharma V, et al. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992–2012[J]. Journal of Allergy and Clinical Immunology, 2015, 135(4): 956–963 337 48.14 7 10.793
17 Simons F E R, Ardusso L R F, Bilò M B, et al. World Allergy Organization anaphylaxis guidelines: summary[J]. Journal of Allergy and Clinical Immunology, 2011, 127(3): 587–593 336 30.55 11 10.793
18 Oettgen H C, Martin T R, Wynshaw-Boris A, et al. Active anaphylaxis in IgE-deficient mice[J]. Nature, 1994, 370(6488): 367–370 333 11.89 28 49.962
19 Bernstein D I, Wanner M, Borish L, et al. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990–2001[J]. Journal of Allergy and Clinical Immunology, 2004, 113(6): 1129–1136 332 18.44 18 10.793
20 Li X M, Serebrisky D, Lee S Y, et al. A murine model of peanut anaphylaxis: T-and B-cell responses to a major peanut allergen mimic human responses[J]. Journal of Allergy and Clinical Immunology, 2000, 106(1): 150–158 329 14.95 22 10.793
21* Bochner B S, Lichtenstein L M. Anaphylaxis.[J]. New England Journal of Medicine, 1991, 324(25):1785–1790 329 10.61 31 91.253
22 Liew W K, Williamson E, Tang M L K. Anaphylaxis fatalities and admissions in Australia[J]. Journal of Allergy and Clinical Immunology, 2009, 123(2): 434–442 322 24.77 13 10.793
23 Brockow K, Jofer C, Behrendt H, et al. Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients[J]. Allergy, 2008, 63(2): 226–232 320 22.86 14 13.146
24 Schwartz, Lawrence B. Diagnostic value of tryptase in anaphylaxis and mastocytosis.[J]. Immunology and Allergy Clinics of North America, 2006, 26(3):451–463 315 19.69 16 3.479
25 Sampson H A, Muñoz-Furlong A, Campbell R L, et al. Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium[J]. Journal of Allergy and Clinical Immunology, 2006, 117(2): 391–397 314 19.63 16 10.793
26 Dombrowicz D, Flamand V, Brigman K K, et al. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene[J]. Cell, 1993, 75(5): 969–976 314 10.83 29 41.584
27 Simons F E R, Ebisawa M, Sanchez-Borges M, et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines[J]. World Allergy Organization Journal, 2015, 8: 32 308 44.00 7 4.084
28* Lieberman P, Camargo Jr C A, Bohlke K, et al. Epidemiology of anaphylaxis: findings of the American college of allergy, asthma and immunology epidemiology of anaphylaxis working group[J]. Annals of Allergy, Asthma and Immunology, 2006, 97(5): 596–602 306 19.13 16 6.347
29* Kemp S F, Lockey R F. Anaphylaxis: a review of causes and mechanisms[J]. Journal of allergy and clinical immunology, 2002, 110(3): 341–348 301 15.05 20 10.793
30 Blumchen K, Ulbricht H, Staden U, et al. Oral peanut immunotherapy in children with peanut anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 2010, 126(1): 83–91 300 25.00 12 10.793
31* Finkelman F D. Anaphylaxis: lessons from mouse models[J]. Journal of Allergy and Clinical Immunology, 2007, 120(3): 506–515 300 20.00 15 10.793
32 Ruëff F, Przybilla B, Biló M B, et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity[J]. Journal of Allergy and Clinical Immunology, 2009, 124(5): 1047–1054 296 22.77 13 10.793
33 Decker W W, Campbell R L, Manivannan V, et al. The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project[J]. Journal of Allergy and Clinical Immunology, 2008, 122(6): 1161–1165 287 20.50 14 10.793
34 Miyajima I, Dombrowicz D, Martin T R, et al. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE-or IgG1-dependent passive anaphylaxis[J]. The Journal of clinical investigation, 1997, 99(5): 901–914 286 11.44 25 14.808
35 Simons F E R. Anaphylaxis.[J]. Journal of Allergy and Clinical Immunology, 2010, 125(2):S161-S181 285 23.75 12 10.793
36 Simons F E R, Roberts J R, Gu X, et al. Epinephrine absorption in children with a history of anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 1998, 101(1): 33–37 273 11.38 24 10.793
37* Neugut A I, Ghatak A T, Miller R L. Anaphylaxis in the United States: an investigation into its epidemiology[J]. Archives of internal medicine, 2001, 161(1): 15–21 272 12.95 21 17.333
38 Tsujimura Y, Obata K, Mukai K, et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis[J]. Immunity, 2008, 28(4): 581–589 268 19.14 14 31.745
39 Poulos L M, Waters A M, Correll P K, et al. Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993–1994 to 2004–2005[J]. Journal of Allergy and Clinical Immunology, 2007, 120(4): 878–884 261 17.40 15 10.793
40 Grabenhenrich L B, Dölle S, Moneret-Vautrin A, et al. Anaphylaxis in children and adolescents: the European Anaphylaxis Registry[J]. Journal of Allergy and Clinical Immunology, 2016, 137(4): 1128–1137 259 43.17 6 10.793
41 Brown A F T, McKinnon D, Chu K. Emergency department anaphylaxis: a review of 142 patients in a single year[J]. Journal of Allergy and Clinical Immunology, 2001, 108(5): 861–866 254 12.10 21 10.793
42 Lieberman P, Nicklas R A, Randolph C, et al. Anaphylaxis—a practice parameter update 2015[J]. Annals of Allergy, Asthma and Immunology, 2015, 115(5): 341–384 253 36.14 7 6.347
43 Bonadonna P, Perbellini O, Passalacqua G, et al. Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels[J]. Journal of allergy and clinical immunology, 2009, 123(3): 680–686 251 19.31 13 10.793
44* Moneret‐Vautrin D A, Morisset M, Flabbee J, et al. Epidemiology of life‐threatening and lethal anaphylaxis: a review[J]. Allergy, 2005, 60(4): 443–451 249 14.65 17 13.146
45 Rivas M N, Burton O T, Wise P, et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 2013, 131(1): 201–212 245 27.22 9 10.793
46 Laxenaire M C, Mertes P M, des Réactions Anaphylactoïdes G E. Anaphylaxis during anaesthesia. Results of a two‐year survey in France[J]. British Journal of Anaesthesia, 2001, 87(4): 549–558 237 11.29 21 9.166
47 Laxenaire M C, Charpentier C, Feldman L. Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study[C]Annales Francaises D'anesthesie et de Reanimation. 1994, 13(3): 301–310 230 8.21 28 1.131
48* Hepner D L, Castells M C. Anaphylaxis during the perioperative period[J]. Anesthesia and Analgesia, 2003, 97(5): 1381–1395 229 12.05 19 5.178
49 Mertes P M, Alla F, Tréchot P, et al. Anaphylaxis during anesthesia in France: an 8-year national survey[J]. Journal of Allergy and Clinical Immunology, 2011, 128(2): 366–373 225 20.45 11 10.793
50 Bohlke K, Davis R L, DeStefano F, et al. Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization[J]. Journal of Allergy and Clinical Immunology, 2004, 113(3): 536–542 223 12.39 18 10.793
51 Mertes PM, Malinovsky JM, Jouffroy L, et al. Reducing the risk of anaphylaxis during anesthesia: 2011 updated guidelines for clinical Practice[J]. Journal of Investigational Allergology and Clinical Immunology. 2011;21(6):442–453 220 20.00 11 7.033
52 Rüggeberg J U, Gold M S, Bayas J M, et al. Anaphylaxis: case definition and guidelines for data collection, analysis, and presentation of immunization safety data[J]. Vaccine, 2007, 25(31): 5675–5684 220 14.67 15 3.641
53 Schwartz L B, Bradford T R, Rouse C, et al. Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis[J]. Journal of clinical immunology, 1994, 14(3): 190–204 220 7.86 28 8.317
54 Strait R T, Morris S C, Yang M, et al. Pathways of anaphylaxis in the mouse[J]. Journal of Allergy and Clinical Immunology, 2002, 109(4): 658–668 219 10.95 20 10.793
55* Pumphrey R. Anaphylaxis: can we tell who is at risk of a fatal reaction?[J]. Current opinion in allergy and clinical immunology, 2004, 4(4): 285–290 216 12.00 18 3.142
56 Strait R T, Morris S C, Finkelman F D. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcγRIIb cross-linking[J]. The Journal of clinical investigation, 2006, 116(3): 833–841 213 13.31 16 14.808
57 Kemp S F, Lockey R F, Wolf B L, et al. Anaphylaxis: a review of 266 cases[J]. Archives of internal medicine, 1995, 155(16): 1749–1754 213 7.89 27 17.333
58* Panesar S S, Javad S, De Silva D, et al. The epidemiology of anaphylaxis in Europe: a systematic review[J]. Allergy, 2013, 68(11): 1353–1361 212 23.56 9 13.146
59 Mangan N E, Fallon R E, Smith P, et al. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells[J]. The Journal of Immunology, 2004, 173(10): 6346–6356 212 11.78 18 5.422
60 Laxenaire MC.Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994-December 1996). Annales Francaises D'anesthesie et de Reanimation. 1999;18(7):796–809 212 9.22 23 1.131
61 Kemp S F, Lockey R F, Simons F E R, et al. Epinephrine: the drug of choice for anaphylaxis–a statement of the World Allergy Organization[J]. World Allergy Organization Journal, 2008, 1: S18-S26 211 15.07 14 4.084
62 Bohlke K, Davis R L, Marcy S M, et al. Risk of anaphylaxis after vaccination of children and adolescents[J]. Pediatrics, 2003, 112(4): 815–820 205 10.79 19 7.125
63 Zabel B A, Nakae S, Zúñiga L, et al. Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis[J]. The Journal of experimental medicine, 2008, 205(10): 2207–2220 202 14.43 14 14.307
64 Wood R A, Camargo Jr C A, Lieberman P, et al. Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States[J]. Journal of Allergy and Clinical Immunology, 2014, 133(2): 461–467 201 25.13 8 10.793
65* Simons F E R, Frew A J, Ansotegui I J, et al. Risk assessment in anaphylaxis: current and future approaches[J]. Journal of allergy and clinical immunology, 2007, 120(1): S2-S24 201 13.40 15 10.793
66 Jerschow E, Lin R Y, Scaperotti M M, et al. Fatal anaphylaxis in the United States, 1999–2010: temporal patterns and demographic associations[J]. Journal of allergy and clinical immunology, 2014, 134(6): 1318–1328 196 24.50 8 10.793
67 Vennekens R, Olausson J, Meissner M, et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4[J]. Nature immunology, 2007, 8(3): 312–320 196 13.07 15 25.606
68 Yunginger J W, Nelson D R, Squillace D L, et al. Laboratory investigation of deaths due to anaphylaxis[J]. Journal of Forensic Science, 1991, 36(3): 857–865 191 6.16 31 1.832
69 Jönsson F, Mancardi D A, Kita Y, et al. Mouse and human neutrophils induce anaphylaxis[J]. The Journal of clinical investigation, 2011, 121(4): 1484–1496 190 17.27 11 14.808
70 Braganza S C, Acworth J P, McKinnon D R L, et al. Paediatric emergency department anaphylaxis: different patterns from adults[J]. Archives of disease in childhood, 2006, 91(2): 159–163 187 11.69 16 3.801
71 Webb L M, Lieberman P. Anaphylaxis: a review of 601 cases[J]. Annals of Allergy, Asthma and Immunology, 2006, 97(1): 39–43 186 11.63 16 6.347
72 Steinke J W, Platts-Mills T A E, Commins S P. The alpha-gal story: lessons learned from connecting the dots[J]. Journal of Allergy and Clinical Immunology, 2015, 135(3): 589–596 183 26.14 7 10.793
73 Metcalfe D D, Peavy R D, Gilfillan A M. Mechanisms of mast cell signaling in anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 2009, 124(4): 639–646 183 14.08 13 10.793
74* Simons F E R, Ardusso L R F, Bilo M B, et al. 2012 Update: World Allergy Organization Guidelines for the assessment and management of anaphylaxis[J]. Current opinion in allergy and clinical immunology, 2012, 12(4): 389–399 180 18.00 10 3.142
75 Cox L, Platts-Mills T A E, Finegold I, et al. American academy of allergy, asthma & immunology/American college of allergy, asthma and immunology joint task force report on omalizumab-associated anaphylaxis[J]. Journal of allergy and clinical immunology, 2007, 120(6): 1373–1377 179 11.93 15 10.793
76 Gold M S, Sainsbury R. First aid anaphylaxis management in children who were prescribed an epinephrine autoinjector device (EpiPen)[J]. Journal of Allergy and Clinical Immunology, 2000, 106(1): 171–176 179 8.14 22 10.793
77* Simons F E R, Ardusso L R F, Dimov V, et al. World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base[J]. International archives of allergy and immunology, 2013, 162(3): 193–204 177 19.67 9 2.749
78 Dohi M, Suko M, Sugiyama H, et al. Food-dependent, exercise-induced anaphylaxis: a study on 11 Japanese cases[J]. Journal of allergy and clinical immunology, 1991, 87(1): 34–40 177 5.71 31 10.793
79 Palosuo K, Alenius H, Varjonen E, et al. A novel wheat gliadin as a cause of exercise-induced anaphylaxis[J]. Journal of Allergy and Clinical Immunology, 1999, 103(5): 912–917 176 7.65 23 10.793
80 Ownby D R, Tomlanovich M, Sammons N, et al. Anaphylaxis associated with latex allergy during barium enema examinations[J]. AJR. American journal of roentgenology, 1991, 156(5): 903–908 174 5.61 31 3.959
81 Yocum, M. W., & Khan, D. A. (1994). Assessment of patients who have experienced anaphylaxis: a 3-year survey. Mayo Clinic Proceedings 69(1), 16–23 172 6.14 28 7.619
82 Vultaggio A, Matucci A, Nencini F, et al. Anti‐infliximab IgE and non‐IgE antibodies and induction of infusion‐related severe anaphylactic reactions[J]. Allergy, 2010, 65(5): 657–661 170 14.17 12 13.146
83* Lieberman P. Biphasic anaphylactic reactions[J]. Annals of allergy, asthma and immunology, 2005, 95(3): 217–226 170 10.00 17 6.347
84 Pumphrey R S H, Roberts I S D. Postmortem findings after fatal anaphylactic reactions[J]. Journal of clinical pathology, 2000, 53(4): 273–276 170 7.73 22 3.411
85 Srivastava K D, Kattan J D, Zou Z M, et al. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy[J]. Journal of Allergy and Clinical Immunology, 2005, 115(1): 171–178 168 9.88 17 10.793
86* Turner P J, Jerschow E, Umasunthar T, et al. Fatal anaphylaxis: mortality rate and risk factors[J]. The Journal of Allergy and Clinical Immunology: In Practice, 2017, 5(5): 1169–1178 167 33.40 5 8.861
87 Mullins R J. Anaphylaxis: risk factors for recurrence[J]. Clinical and Experimental Allergy, 2003, 33(8): 1033–1040 167 8.79 19 5.018
88 Helbling A, Hurni T, Mueller U R, et al. Incidence of anaphylaxis with circulatory symptoms: a study over a 3‐year period comprising 940 000 inhabitants of the Swiss Canton Bern[J]. Clinical and Experimental Allergy, 2004, 34(2): 285–290 166 9.22 18 5.018
89 Novembre E, Cianferoni A, Bernardini R, et al. Anaphylaxis in children: clinical and allergologic features[J]. Pediatrics, 1998, 101(4): 166 6.92 24 7.125
90 Ross M P, Ferguson M, Street D, et al. Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System[J]. Journal of Allergy and Clinical Immunology, 2008, 121(1): 166–171 165 11.79 14 10.793
91* Kroigaard M, Garvey L H, Gillberg L, et al. Scandinavian Clinical Practice Guidelines on the diagnosis, management and follow‐up of anaphylaxis during anaesthesia[J]. Acta anaesthesiologica scandinavica, 2007, 51(6): 655–670 165 11.00 15 2.105
92 Kelso J M, Jones R T, Yunginger J W. Anaphylaxis to measles, mumps, and rubella vaccine mediated by IgE to gelatin[J]. Journal of allergy and clinical immunology, 1993, 91(4): 867–872 165 5.69 29 10.793
93 Olivera A, Mizugishi K, Tikhonova A, et al. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis[J]. Immunity, 2007, 26(3): 287–297 164 10.93 15 31.745
94 Akin C, Scott L M, Kocabas C N, et al. Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis[J]. Blood, 2007, 110(7): 2331–2333 164 10.93 15 23.629
95 Haeberli G, Brönnimann M, Hunziker T, et al. Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy[J]. Clinical and Experimental Allergy, 2003, 33(9): 1216–1220 164 8.63 19 5.018
96 Mehl A, Wahn U, Niggemann B. Anaphylactic reactions in children–a questionnaire‐based survey in Germany[J]. Allergy, 2005, 60(11): 1440–1445 163 9.59 17 13.146
97 Shida K, Takahashi R, Iwadate E, et al. Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model[J]. Clinical and Experimental Allergy, 2002, 32(4): 563–570 163 8.15 20 5.018
98* De Silva I L, Mehr S S, Tey D, et al. Paediatric anaphylaxis: a 5 year retrospective review[J]. Allergy, 2008, 63(8): 1071–1076 158 11.29 14 13.146
99* Simons F E R. Anaphylaxis: recent advances in assessment and treatment[J]. Journal of Allergy and Clinical Immunology, 2009, 124(4): 625–636 156 12.00 13 10.793
100 Shadick N A, Liang M H, Partridge A J, et al. The natural history of exercise-induced anaphylaxis: survey results from a 10-year follow-up study[J]. Journal of allergy and clinical immunology, 1999, 104(1): 123–127 156 6.78 23 10.793

*Review