Comparison 3. Letrozole compared to SERMs with our without adjuncts, followed by IUI.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Ovarian hyperstimulation syndrome rate	2	1494	Risk Difference (M‐H, Fixed, 95% CI)	‐0.00 [‐0.01, 0.00]
3.1.1 AI versus clomiphene	1	107	Risk Difference (M‐H, Fixed, 95% CI)	‐0.02 [‐0.07, 0.03]
3.1.2 AI versus clomiphene + rFSH and rFSH only	1	1387	Risk Difference (M‐H, Fixed, 95% CI)	‐0.00 [‐0.01, 0.00]
3.2 Clinical pregnancy rate	3	1597	Odds Ratio (M‐H, Fixed, 95% CI)	1.71 [1.30, 2.25]
3.2.1 AI versus clomiphene	2	210	Odds Ratio (M‐H, Fixed, 95% CI)	2.09 [0.97, 4.53]
3.2.2 AI versus clomiphene + rFSH and rFSH only	1	1387	Odds Ratio (M‐H, Fixed, 95% CI)	1.66 [1.23, 2.22]
3.3 Miscarriage rate per woman	2	1490	Odds Ratio (M‐H, Fixed, 95% CI)	1.22 [0.62, 2.40]
3.3.1 AI versus clomiphene	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 8.06]
3.3.2 AI versus clomiphene + rFSH and rFSH only	1	1387	Odds Ratio (M‐H, Fixed, 95% CI)	1.32 [0.66, 2.65]
3.4 Miscarriage rate per pregnancy	2	260	Odds Ratio (M‐H, Fixed, 95% CI)	0.76 [0.37, 1.57]
3.4.1 AI versus clomiphene	1	15	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.00, 3.09]
3.4.2 AI versus clomiphene + rFSH and rFSH only	1	245	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.40, 1.79]
3.5 Multiple pregnancy rate	3	1597	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.49, 2.13]
3.5.1 AI versus clomiphene	2	210	Odds Ratio (M‐H, Fixed, 95% CI)	3.48 [0.14, 87.49]
3.5.2 AI versus clomiphene + rFSH and rFSH only	1	1387	Odds Ratio (M‐H, Fixed, 95% CI)	0.94 [0.44, 2.03]