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. 2022 Sep 27;2022(9):CD010287. doi: 10.1002/14651858.CD010287.pub4

Comparison 4. Letrozole compared to laparoscopic ovarian drilling.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 Live birth rate 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.2 Clinical pregnancy rate 3 367 Odds Ratio (M‐H, Fixed, 95% CI) 1.47 [0.95, 2.28]
4.2.1 AI versus LOD 2 221 Odds Ratio (M‐H, Fixed, 95% CI) 1.69 [0.96, 2.97]
4.2.2 AI + metformin versus LOD 1 146 Odds Ratio (M‐H, Fixed, 95% CI) 1.20 [0.60, 2.39]
4.3 Miscarriage rate per woman 3 367 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.31, 2.44]
4.3.1 AI versus LOD 2 221 Odds Ratio (M‐H, Fixed, 95% CI) 0.58 [0.14, 2.50]
4.3.2 AI + metformin versus LOD 1 146 Odds Ratio (M‐H, Fixed, 95% CI) 1.35 [0.29, 6.27]
4.4 Miscarriage rate per pregnancy 3 122 Odds Ratio (M‐H, Fixed, 95% CI) 0.65 [0.22, 1.92]
4.4.1 AI versus LOD 2 73 Odds Ratio (M‐H, Fixed, 95% CI) 0.38 [0.08, 1.72]
4.4.2 AI + metformin versus LOD 1 49 Odds Ratio (M‐H, Fixed, 95% CI) 1.21 [0.24, 6.09]
4.5 Multiple pregnancy rate 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only