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. Author manuscript; available in PMC: 2022 Sep 27.
Published in final edited form as: J Mech Behav Biomed Mater. 2021 Oct 31;125:104921. doi: 10.1016/j.jmbbm.2021.104921

Fig. 4. Characterization of the effects of various types of mutations, predicted by ColGen.

Fig. 4.

a) Tm values of mutations in G, P, or O position demonstrates that mutations in the middle of the sequence are the most destabilizing for Tm values. Mutations in the G position are the most destabilizing to the peptide. Error bars indicate standard deviation of all amino acids that were mutated. b) Thermal stability as a function of collagen sequence length, where length is number of repeat units (GOP) demonstrates that there is a critical length at which the Tm can no longer be increased significantly. This critical length is consistent with other studies.85