TABLE 1.
Expression and function of IL-23 in autoimmune diseases.
| Autoimmune diseases | Expression level of IL-23 in serum/plasma (PMID) | Function role of IL-23 | References |
|---|---|---|---|
| Psoriasis | Human (+) | IL-23 stimulates Th17 cells to produce IL-17 and IL-22 | 28165883 |
| IL-23 is the main upstream regulator of psoriasis | 14707118 | ||
| SLE | Human (+) | IL-23 increased the ratio of IL-17 to IFN-c | 20513356 |
| RA | Human (+) | IL-23 influences T cell phenotype in SLE | 22012611 |
| IBD | Human (+) | IL-23 Promote and enhance the secretion of IL-17 by TH17 cells | 29441874 |
| AS | Human (+) | IL-23 stimulates the transformation of CD4+ T cells into Th17 cells | 25288779 |