FIGURE 3.

Gross photographs (a) and histopathological images of the resected kidney (b, c) and ureter (d). (a) The right kidney and ureter are massively dilated and filled with urine. The black dotted lines represent the three different locations from which the histological analyses were performed. (b) Greater than 90% of the renal parenchyma is replaced by an extensively dilated renal pelvis. Bar = 8 mm. (c) Amplified image of the area marked by the black dashed square line in Figure 3b shows that the remaining thin rim of atrophic renal tissue is largely composed of fibrotic tissue and rare renal tubules. Bar = 200 μm. (d) Histologic image obtained from the proximal part of the ureter shows piled neoplastic cells confined by the basement membrane (carcinoma in situ) with mitotic figures (white arrows). No neoplasia was observed in the middle and distal parts of the ureter. Bar = 60 μm. Prox, proximal; Mid, middle; Dist, distal; RP, renal pelvis