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. 2022 Sep 2;13:953917. doi: 10.3389/fimmu.2022.953917

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Copyright © 2022 Fernández-Quintero, Fischer, Kokot, Waibl, Seidler and Liedl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contact analysis of the HSA antigen with the parent E06 VNAR and the huE06 v1.1. (A) Interaction fingerprint visualization of the contacts between antibody and antigen, depicts the differences in the contact frequencies between the parent and the humanized variant. (B) Interacting residues between antibody and antigen color-coded according to their occurrence. (C) Interaction flareplots between antibody (dark grey) and antigen HSA (light grey). The color-coding of the lines in the flareplots corresponds to the occurrence of the contacts. (D) Contacts per frame distributions for the interactions of the parent and the humanized variant with the antigen. The distribution of the parent is depicted in blue, the distribution of huE06 v1.1 is illustrated in green.