FIG. 1.
The fosB(yndN) gene encodes a fosfomycin resistance protein. (A) The fosB(yndN) region of the chromosome is illustrated. The fosB gene is transcribed from a ςW-dependent promoter similar in sequence to the sigW autoregulatory promoter, Pw (9). (B) Multiple sequence alignment of the 144-amino-acid B. subtilis FosB protein (Bsu) with FosB from S. epidermidis (63% identity [21]) and with FosA from Tn2921 (33% identity [14]). Residues identical in all three protein sequences are shown in bold, and those residues identical between the more closely related FosB homologs are underlined in the B. subtilis sequence.