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. 2022 Feb 16;35(10):1431–1438. doi: 10.1038/s41379-022-01016-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Example of 2D analysis of an NLPHL pattern A case showing LP cells with multilobated nuclei (OCT2-immunostaining, LP cells encircled in red). B Example of 2D analysis of a THRLBCL case showing tumor cells with angulated nuclei (OCT2-immunostaining, tumor cells encircled in red). C Nuclear perimeters of tumor cells from NLPHL patterns (A, C, D, and E) and THRLBCL in 2D analysis. D Nuclear areas of tumor cells from NHLPL patterns (A, C, D, and E) and THRLBCL in 2D analysis.