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. 2022 Apr 10;49(10):9687–9697. doi: 10.1007/s11033-022-07427-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig.2 — Underlying mechanisms of some lncRNAs in recurrent miscarriage (RM). Some lncRNAs play crucial roles in RM by sponging miRNAs or interacting with other proteins. a H19 interacts with miRNAs of Let-7 to regulate the transcription and translation of integrin β3. b lnc-49a can positively regulate CD49a expression. c lnc-SLC4A1-1 recruit NF-κB and bind to the CXCL8 promoter, which leads to upregulation of CXCL8. d lncRNA SNHG7 interacts with miR-34a to regulate the progression of RM through the Wnt/β-catenin signaling pathway. e lncRNA HOTAIR activates the PI3K-AKT signaling pathway to promote MMP-2 expression. f overexpression lnc-HZ08 suppressed the PI3K and AKT protein levels, and the downstream proteins CDK2 and p-P21. g lnc-HZ01 promotes the transcription of MXD1 mRNA, which promotes the transcription of METTL14 mRNA. h H19 interacts with miR675 to regulate the progression of RM.