Table 1.
Correlation of pre-CCRT SPINK1 expression with clinicopathological parameters in RC patients
| Variables | n | SPINK1 expression | ||
|---|---|---|---|---|
| High | Low | p value | ||
| Total | 111 | 21 (18.9%) | 90 (80.1%) | |
| Age (y/o) | 0.804 | |||
| ≦ 75 | 69 (62.2%) | 14 (20%) | 55 (80%) | |
| > 75 | 42 (37.8%) | 7 (16.7%) | 35 (83.3%) | |
| Gender | 0.078 | |||
| Male | 69 (62.2%) | 17 (24.6%) | 52 (75.4%) | |
| Female | 42 (37.8%) | 4 (9.5%) | 38 (90.5%) | |
| Tumor grade | 0.123 | |||
| G1 and G2 | 104 (93.7%) | 18 (17.3%) | 86 (82.7%) | |
| G3 | 7 (6.3%) | 3 (42.9%) | 4 (57.1%) | |
| Lymph-vascular invasion | 1.000 | |||
| Negative | 86 (77.4%) | 16 (18.6%) | 70 (81.4%) | |
| Positive | 25 (22.6%) | 5 (20%) | 20 (80%) | |
| Perineural invasion | 0.028* | |||
| Negative | 81 (73%) | 11 (13.6%) | 70 (86.4%) | |
| Positive | 30 (27%) | 10 (33.3%) | 20 (66.7%) | |
| Tumor stage (ypT) | 0.334 | |||
| ypT0–2 | 47 (42.3%) | 11 (23.4%) | 36 (76.4%) | |
| ypT3–4 | 64 (57.7%) | 10 (15.6%) | 54 (85.4%) | |
| Lymph node stage (ypN) | 0.799 | |||
| ypN0 | 73 (65.8%) | 13 (17.8%) | 60 (82.2%) | |
| ypN1–2 | 38 (34.2%) | 8 (21.1%) | 30 (78.9%) | |
| Metastasis status (ypM) | 0.264 | |||
| No | 98 (88.2%) | 17 (17.3%) | 81 (82.7%) | |
| Yes | 13 (11.8%) | 4 (30.8%) | 9 (69.2%) | |
| Disease stage | 0.327 | |||
| Early (I and II) | 69 (62.2%) | 11 (15.9%) | 58 (84.1%) | |
| Late (III and IV) | 42 (37.8%) | 10 (23.8%) | 32 (76.2%) | |
| Tumor regression score | 0.006* | |||
| 0–1 | 46 (41.4%) | 3 (6.5%) | 43 (93.5%) | |
| 2–3 | 65 (58.6%) | 18 (27.7%) | 47 (72.3%) | |
*Statistically significant (p < 0.05)