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. 2022 Sep 27;8:96. doi: 10.1038/s41421-022-00440-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic overview of mouse embryo preparation and metabolome profiling during mouse pre-implantation embryo development. b Venn diagram showing the overlap among metabolites across all stages. The number of significantly abundant metabolites is shown in red. c Alluvial plots of the global dynamics of high, intermediate, and low metabolites based on their levels during early embryo development. d UMAP analysis. Metabolites marked with the same color represent six replicates of the same stage. e Heatmap of metabolite dynamics during mouse embryo development, classified according to metabolic pathways. f KEGG analysis of abundant metabolites in each stage.