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. 2022 Sep 27;8:96. doi: 10.1038/s41421-022-00440-z

Fig. 7. NAD+ supplement promotes the removal of zygotic H3K27ac and benefits preimplantation development of human embryos.

Fig. 7

a Representative confocal images of control and NMN-treated human embryos stained with H3K27ac antibody. Scale bars, 50 µm. b Sirtuin family expression patterns according to RNA-seq data in human pre-implantation embryos. c Stacked bar plots showing fraction of human embryos at the different developmental stages after NMN addition (right side, n = 11), or control (left side, n = 9). d Representative images of the development of NMN-treated human embryos. e Metabolic characteristics during mouse pre-implantation development (upper) and a model of NAD+ involvement in the precise and timely regulation of minor ZGA (below).