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. 2022 Sep 27;6:45. doi: 10.1038/s41538-022-00161-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Variations in (a) Venn diagram of the overlap at OTU level. (b) The discovered species. (c) The alpha diversity (Shannon index). (d) The Bacteroidetes/Firmicutes ratio. (e) Overall gut microbial structure, principal co-ordinates analysis based on the Bray-Curtis distance. (f) The relative abundance on phylum level. (g) The relative abundance on genus level. FHVD-Pre (n = 25), FHVD-Post (n = 25), NFHVD-Pre (n = 18), and NFHVD-Post (n = 18). OTU, Operational Taxonomic Unit. Wilcoxon matched pair signed-rank tests (two tailed) were used to analyze pairwise Pre and Post within diets. A Mann-Whitney test was used to analyze differences between the FHVD and NFHVD groups at the same time point. *P < 0.05 and **P < 0.01. The bounds, whiskers and percentile of each box plot represented maximum, 75 percentile, median, 25 percentile and minimum from the top to the bottom respectively.