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. 2022 Sep 27;6:45. doi: 10.1038/s41538-022-00161-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Changes in fecal concentrations of (a) acetate, (b) propionate, and (c) butyrate. Changes in the abundance of genes that encode the key enzymes in (d) acetate production [formate-tetrahydrofolate ligase fhs and acetate kinase ack], (e) propionate production [lactoyl-CoA dehydratase lcd, propionaldehyde dehydrogenase pduP, and methylmalonyl-CoA decarboxylase mmd], and (f) butyrate production [butyryl–coenzyme A (butyryl-CoA):acetate CoA transferase but and butyrate kinase buk]. The bounds, whiskers and percentile of each box plot represented maximum, 75 percentile, median, 25 percentile and minimum from the top to the bottom respectively.