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Effect of ASP5736 (0.01–0.1 mg/kg, po) on prepulse inhibition (PPI). The prepulse was (A) 70 dB, (B) 75 dB, and (C) 80 dB. Wild-type rats and vehicle-treated Fmr1-knockout (KO) rats were administered 0.5% methyl cellulose instead of ASP5736. Values are mean ± SEM. A total of 15 (wild type, vehicle of Fmr1-KO, 0.01 mg/kg and 0.03 mg/kg group) and 14 (0.1 mg/kg group) rats were used. *P < .05, **P < .01, compared with vehicle of Fmr1-KO rats (Dunnett’s multiple comparisons test).
