Fig. 10.

Representative photomicrographs of H&E-stained striata of different experimental groups. A Negative control brains showing the normal histological architecture with intact neurons. B CIS-induced brains showing necrosis of neurons (arrow). C N.SF-alone treated brains, showing no histopathological alterations. D CIS + N.SF-treated brains showing shrunken and necrosis of sporadic neurons (arrow). E CIS + SF-treated brains showing necrosis of some neurons (arrow) (scale bar: 50 μm). F Total histological scoring of striatum damage. Results are presented as mean ± standard error of the mean (SEM). Mean with different letters (a–d) is significant at p ≤ 0.05