Fig. 12.

Representative photomicrographs of H&E-stained cerebellum of different experimental groups. A Negative control brains showing the normal histological architecture. B CIS-neurotoxicated brains showing pyknotic and shrunken Purkinje cells (arrow). C N.SF alone treated brains showing normal histological structure. D and E CIS + N.SF- and CIS + SF-treated brains, respectively, showing degeneration of sporadic Purkinje cells (arrow) (scale bar: 50 μm). F Total histological scoring of cerebellum damage. Results are presented as mean ± standard error of the mean (SEM). Mean with different letters (a–c) is significant at p ≤ 0.05