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. 2022 Aug 15;40(5):1479–1498. doi: 10.1007/s12640-022-00555-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Effect of intranasal administration of sulforaphane (SF) loaded within iron oxide nanoparticles (N.SF) or free sulforaphane (SF) on brain contents of lipid peroxides (LPO), glutathione reduced (GSH), and nitric oxide (NO) in CIS-induced rats. Groups: negative control rats, cisplatin (CIS)-exposed rats, N.SF-alone exposed rats, CIS + N.SF-treated rats, and CIS + SF-treated rats. Results are presented as mean ± standard error of the mean (SEM). Mean with different letters (a–d) is significant at p ≤ 0.05