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. 2022 Sep 27;5:1018. doi: 10.1038/s42003-022-04004-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Wound epithelium (WE) formation in geckos in high (28 °C) and low temperature groups (17 °C and 10 °C). b Number of regenerated geckos in high (28 °C) and low temperature groups (17 °C and 10 °C), N = 10 for each group. c ATP levels in liver and tail tissue in geckos from high (28 °C) and low temperature groups (17 °C and 10 °C), N = 7–8. d–j Serum glucose (GLU), cholesterol (CHOL), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), uric acid (UA), and creatinine (CR) concentration, N = 4–5. k Immunohistochemical analysis of WE6 (marker of wound epithelium) staining in control and low temperature groups (17 °C and 10 °C, respectively). Solid line indicates the caudal border of wound epithelium, dotted line indicates border between wound epithelium and blastema. Scale bar = 50 µm. Values represent means ± SD, ^nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001.