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. 2022 Sep 27;13(9):829. doi: 10.1038/s41419-022-05279-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A, B MXD1 silencing did reduce MXD1, but not HOXA5 expression, and partially rescued the expression of mitosis-related genes in ECCA cells. C–E MXD1 silencing abrogated the inhibition of HOXA5 overexpression on the cell cycle and proliferation of ECCA cells. F MXD1 silencing partially rescued the tumor volumes in the HOXA5 over-expressing ECCA tumors from nude mice. G Immunohistochemistry analysis of MXD1 and Ki67 expression in xenograft tumors from nude mice. *P < 0.05. **P < 0.01. ***P < 0.001. Orange bar, 50 μm. Green bar, 20 μm.