Table 2.
Association of Demographic and Histopathologic Characteristics With Human Epidermal Growth Factor Receptor 2 (HER2) Overexpression (3+ Only) for Patients With Gastric Carcinoma (N = 150)
| Variable | HER2 Status | P Value | |
|---|---|---|---|
| Positive, No. (%) | Negative, No. (%) | ||
| Age | .80 | ||
| 19–40 y | 2 (8.7) | 21 (91.3) | |
| 41–60 y | 3 (4.2) | 69 (95.8) | |
| ≥61 y | 4 (7.3) | 51 (92.7) | |
| Sex | .42 | ||
| Male | 7 (7.1) | 91 (92.9) | |
| Female | 2 (3.8) | 50 (96.2) | |
| Histologic subtype | .01 | ||
| Intestinal type | 9 (11.7) | 68 (88.3) | |
| Diffuse type | 0 (0.0) | 41 (100.0) | |
| Mixed type | 0 (0.0) | 32 (100.0) | |
| Histologic grade | |||
| Well differentiated | 8 (17.4) | 38 (82.6) | |
| Moderately differentiated | 1 (1.9) | 53 (98.1) | |
| Poorly differentiated | 0 (0.0) | 50 (100.0) | |
| Type of specimen | .002 | ||
| Biopsies | 7 (17.1) | 34 (82.9) | |
| Resection | 2 (1.8) | 107 (98.2) | |
| Tumor location | >.99 | ||
| Gastric | 8 (6.5) | 115 (93.5) | |
| Gastroesophageal junction | 1 (3.7) | 26 (96.3) | |