Table I.
Top 10 most significantly upregulated and downregulated genes in WT brain versus WT blood CD8+ T cells sorted after p values
| Gene | Description | Fold Change (log2) | p Value (<0.05) |
|---|---|---|---|
| Xcl1 | Chemokine (C motif) ligand 1 | 2.13 | 2.95E−09 |
| Isg20 | IFN-stimulated protein | 2.29 | 8.55E−07 |
| Dusp2 | Dual specificity phosphatase 2 | 2.00 | 1.80E−05 |
| Cxcr6 | CXCR6 | 1.24 | 4.88E−05 |
| Mdfic | MyoD family inhibitor domain containing | 4.73 | 9.32E−05 |
| Itga1 | Integrin α1 | 3.11 | 9.11E−05 |
| Trnt1 | tRNA nucleotidyl transferase, CCA-adding, 1 | 2.97 | 7.63E−05 |
| Pmepa1 | Prostate transmembrane protein, androgen-induced 1 | 2.59 | 1.18E−04 |
| Cish | Cytokine inducible SH2-containing protein | 1.49 | 4.14E−04 |
| Chd3 | Chromodomain helicase DNA binding protein 3 | 1.11 | 4.03E−04 |
| Klf2 | Krüppel-like factor 2 (lung) | −2.34 | 4.40E−14 |
| Hbb-bs | Hemoglobin, β adult S chain | −3.63 | 2.98E−10 |
| Klf3 | Krüppel-like factor 3 (basic) | −2.24 | 1.60E−09 |
| Hba-a2 | Hemoglobin α, adult chain 2 | −3.83 | 3.01E−09 |
| Gzmm | Granzyme M (lymphocyte met-ase 1) | −3.82 | 3.72E−08 |
| Ccl5 | CCL5 | −1.19 | 9.64E−08 |
| Hba-a1 | Hemoglobin α, adult chain 1 | −3.89 | 2.25E−07 |
| Gzma | Granzyme A | −3.44 | 4.27E−05 |
| Arl4c | ADP-ribosylation factor-like 4C | −1.31 | 7.63E−05 |
| Hbb-bt | Hemoglobin, β adult T chain | −3.74 | 8.49E−05 |