Table II.
Top 10 most significantly upregulated and downregulated genes in APP-PS1 brain versus APP-PS1 blood CD8+ T cells sorted after p values
| Gene | Description | Fold Change (log2) | p Value (<0.05) |
|---|---|---|---|
| Cxcr6 | CXCR6 | 1.90 | 1.20E−05 |
| Ccnd2 | Cyclin D2 | 1.40 | 8.22E−05 |
| Id2 | Inhibitor of DNA binding 2 | 1.08 | 1.11E−04 |
| Isg20 | IFN-stimulated protein | 3.61 | 1.35E−04 |
| Efhd2 | EF hand domain containing 2 | 1.74 | 1.58E−04 |
| Litaf | LPS-induced TNF factor | 5.22 | 1.67E−04 |
| Xcl1 | Chemokine (C motif) ligand 1 | 2.27 | 1.70E−04 |
| Ppp1r16b | Protein phosphatase 1, regulatory subunit 16B | 1.55 | 2.43E−04 |
| Casp1 | Caspase 1 | 2.08 | 6.58E−04 |
| Rnf115 | Ring finger protein 115 | 4.41 | 8.36E−04 |
| Klf2 | Krüppel-like factor 2 (lung) | −3.37 | 7.18E−17 |
| Klf3 | Krüppel-like factor 3 (basic) | −3.90 | 6.34E−13 |
| Ccr7 | CCR7 | −4.73 | 1.38E−09 |
| Hbb-bs | Hemoglobin, β adult S chain | −4.22 | 2.84E−08 |
| Hba-a2 | Hemoglobin α, adult chain 2 | −4.36 | 5.78E−08 |
| Ier2 | Immediate early response | −2.17 | 1.94E−07 |
| Hba-a1 | Hemoglobin α, adult chain 1 | −4.98 | 1.96E−07 |
| Limd2 | LIM domain containing 2 | −1.22 | 9.24E−06 |
| Lef1 | Lymphoid enhancer binding factor 1 | −2.20 | 1.17E−05 |
| Junb | Jun B proto-oncogene | −1.39 | 2.46E−05 |