Table III.
List of top 10 significantly upregulated KEGG pathways and their corresponding genes in APP-PS1 brain versus APP-PS1 blood CD8+ T cells sorted after adjusted p values
| Pathway | Genes | Adjusted p Value (<0.05) |
|---|---|---|
| EBV infection | Ccnd2/Cd3g/Irf9/Psmd2/Ifnar2/Nfkb2/Cd3e/Nedd4/Isg15/Cdk6/H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 3.96E−04 |
| Endocytosis | Ap2a2/Rabep1/Cblb/Agap2/Smap1/Clta/Nedd4/Eea1/Rab11fip2/Sh3kbp1/Arf3/H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 3.96E−04 |
| Cellular senescence | Ccnd2/Mapkapk2/Ppp3cc/Ppp3ca/Itpr1/Eif4ebp1/Cdk6/H2-T22/H2-T22/Rbbp4/H2-Q7/H2-Q7/H2-Q6 | 3.96E−04 |
| Kaposi sarcoma−associated herpesvirus infection | Irf9/Mapkapk2/Pik3cg/Ppp3cc/Ifnar2/Ppp3ca/Itpr1/Cdk6/Gng2/H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 3.96E−04 |
| HIV1 infection | Cd3g/Apobec3/Ppp3cc/Ppp3ca/Itpr1/Cd3e/Skp1a/Gng2/H2-T22/H2-T22/Trim30d/H2-Q7/H2-Q7/H2-Q6 | 9.00E−04 |
| Human CMV infection | Gna13/Ppp3cc/Ppp3ca/Itpr1/Eif4ebp1/Ptger4/Cdk6/Gng2/ H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 6.37E−03 |
| C-type lectin receptor signaling pathway | Irf9/Mapkapk2/Ppp3cc/Cblb/Nfkb2/Casp1/Ppp3ca/Itpr1 | 1.07E−02 |
| Measles | Ccnd2/Cd3g/Irf9/Cblb/Ifnar2/Csnk2b/Ifih1/Cd3e/Cdk6 | 1.15E−02 |
| Human T cell leukemia virus 1 infection | Ccnd2/Cd3g/Ppp3cc/Nfkb2/Xiap/Ppp3ca/Cd3e/H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 1.17E−02 |
| Ag processing and presentation | Rfxap/Cd8a/H2-T22/H2-T22/H2-Q7/H2-Q7/H2-Q6 | 1.37E−02 |