Table 2.
Cox regression and propensity-matched analyses for IRT and all-cause in-hospital mortality in patients with reperfusion therapy.
| Unmatched analyses | Propensity-matched analyses c | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | Unadjusted | Adjusted | ||||||
| HR (95% CI) | p -value | HR (95% CI) | p -value | HR (95% CI) | p -value | HR (95% CI) | p -value | ||
| Thrombolysis-only group a | |||||||||
| IRT- | 1 (Reference) | NA | 1 (Reference) | NA | 1 (Reference) | NA | 1 (Reference) | NA | |
| IRT+ | 0.20 (0.19–0.22) | <0.0001 | 0.18 (0.16–0.20) | <0.0001 | 0.25 (0.22–0.29) | <0.0001 | 0.23 (0.20–0.26) | <0.0001 | |
| EVT group b | |||||||||
| IRT- | 1 (Reference) | NA | 1 (Reference) | NA | 1 (Reference) | NA | 1 (Reference) | NA | |
| IRT+ | 0.11 (0.10–0.13) | <0.0001 | 0.13 (0.12–0.15) | <0.0001 | 0.21 (0.18–0.24) | <0.0001 | 0.18 (01.5–0.21) | <0.0001 | |
EVT, endovascular therapy; HR, hazard ratio; IRT, inpatient rehabilitation therapy.
The model adjusted for patient age, hospital level, TOAST, reperfusion time, use of antiplatelet within 48 h, use of statin, NIHSS score at 24 h, NIHSS score change at 24 h, and intracranial hemorrhage, shown in Supplementary Table S12. A total of 159,229 patients were included in the model. Missing data are shown in Supplementary Tables S3, S4.
The model adjusted for patient age, hospital level, TOAST, reperfusion time, reperfusion status, use of antiplatelet within 48 h, use of statin, NIHSS score at 24 h, NIHSS score change at 24 h, and intracranial hemorrhage, shown in Supplementary Table S13. A total of 31,956 patients were included in the model. Missing data are shown in Supplementary Tables S3, S4.
Matched on propensity score with age, sex, hospital level, region, mRS at admission, NIHSS score at admission, NIHSS score at 24 h, NIHSS score change at 24 h, TOAST, onset-to-needle time, thrombolytic drugs, use of antiplatelet within 48 h, use of statin, intracranial hemorrhage, and period of COVID-19 in the thrombolysis-only group. Matched on propensity score with age, sex, hospital level, region, mRS at admission, NIHSS score at admission, NIHSS score at 24 h, NIHSS score change at 24 h, TOAST, onset-to-puncture time, reperfusion status, type of EVT (direct EVT or bridging thrombolysis), use of antiplatelet within 48 h, use of statin, intracranial hemorrhage, and period of COVID-19 in the EVT group.