Figure 2.

Immune responses after IL-2 discontinuation. Fold change from baseline in CD4+ regulatory T cell (Treg), CD4+ conventional T cell (Tcon), and CD8+ T cell numbers after stopping low-dose IL-2 therapy is shown for patients who had available immune cell data. Baseline was considered as the earliest time point prior to IL-2 discontinuation where immune cell data was obtained except for in 3 patients (C5, C12, and C14), who had data available on the day of IL-2 discontinuation (time point 0). Each graph represents data from an individual patient. Treg are represented by black lines, Tcon by orange lines, Treg/Tcon ratio by gray lines, and CD8+ T cells by blue lines. The time period prior to IL-2 discontinuation is shaded in light gray. Black arrows represent the time of IL-2 discontinuation.