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. 2022 Sep 14;13:972590. doi: 10.3389/fneur.2022.972590

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Copyright © 2022 Maher, D'Souza, Zeng, Barnett, Kavehei, Nikpour and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean group differences in TW-TM for each whole brain tract. Grouped boxplots for each TW-TM for each whole brain tract are shown in (A). A single asterisk denotes the tracts where the mean TW-TM difference between the two patient groups was significant (p < 0.05), whereas two asterisks denote the tracts where the mean TW-TM difference was significant between the FBTCS-Y and control groups (p < 0.05). In panel (B) is a visual representation of the whole-tracts where a significant difference in mean TW-TM was observed between the two patient groups (light blue: inferior fronto-occipital fascicle, metrics: TW-ADC and TW-AD; dark blue: striato-occipital tract, metric: TW-ADC and TW-AD; green: thalamo-occipital tract, metric: TW-ADC). Also shown in panel (B) is the middle cerebellar peduncle (MCP, purple) where a significant difference in mean TW-AD was observed between the FBTCS-Y and control groups. Notably, the mean TW-AD of the middle cerebellar peduncle was significantly different between all patients and controls. Splitting the patients into their subgroups revealed the significant difference was driven by the FBTCS-Y group.