Figure 5.

The primary findings from Figures 2 and 3 (KYNA and KYNA/KYN) are examined for aetiological associations in epileptic spasms. Comparison of CSF KYNA and KYNA/KYN ratio in the unknown aetiology epileptic spasms subgroup (n=15) with the known aetiology (genetic-structural) epileptic spasms subgroup (n=19), and statistically compared using the Mann-Whitney U test. Other non-inflammatory neurological controls (OND, n=29) are presented for comparison, but are not included in statistical testing. KYNA was not lower in the unknown aetiology subgroup compared to the gene-structural subgroup (p=0.838) (Mann Whitney U test). Although KYNA/KYN was lower in unknown aetiology subgroup compared to gene-structural subgroup, the finding was not statistically significant (p=0.164) (Mann Whitney U test).