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View full-text article in PMC

. 2022 Sep 26;84:104280. doi: 10.1016/j.ebiom.2022.104280

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The primary findings from Figures 2 and 3 (KYNA and KYNA/KYN) are examined for steroid responsiveness in epileptic spasms. KYNA and KYNA/KYN ratio are presented in steroid responders (n=7), partial steroid responders (n=18) and steroid refractory (n=6) patients. OND group (n=29) are presented for comparison, but not subjected to statistical testing. KYNA is lower in the steroid partial responders compared to the steroid refractory patients (p=0.0183) (Mann Whitney U test). KYNA/KYN ratio is lower in the steroid partial responder group compared to the steroid refractory group (p=0.0183) (Mann-Whitney U test), and KYNA/KYN is lower in the steroid responder group compared to the steroid refractory group (p=0.0047) (Mann-Whitney U test). The comparison of groups were analysed by the Mann-Whitney U test, and uncorrected p values are presented.