Table 1.
The influence of antidepressants on Th17-cells function.
| Drug | Disease | The effect on Th17-cells | Authors |
|---|---|---|---|
| Combined treatment with desloratadine (histamine H1-receptor antagonist) and nortriptyline (tricyclic-antidepressant [TCA]) | Mice with relapsing-remitting EAE | The combined in vivo treatment with deloratadine (3 mg/kg) and Nortriptyline (10 mg/kg) decreases the IL-17 production by PLP or anti-CD3-activated splenocytes and anti-CD3-activated lymph node cells in mice with EAE. Nortriptyline (0–1mM) dose-dependently reduced IL-17 production by PLP and OVA activated lymph node cells and anti-CD3/anti-CD28-activated naive CD4+ T-cells. | Podojil et al., 2011 (67) |
| Desipramine (TCA) | Mice with allergic rhinitis (AR) and depression | Desipramine administration (3 mg/kg, 10 mg/kg or 30 mg/kg) decreased CD4+IL-17+/CD4+ T-cells ratio in AR mice spleen cells. | Zhang et al., 2013 (68) |
| Amitriptyline (TCA) | Mice with C. rodentium infection | Treatment with amitriptyline (180 mg/l via drinking water for 14 days before infection and 10 days during infection) enhance frequencies of CD4+IL-17+ and CD4+IFN-γ+ T-cells cells through acid sphingomyelinase inhibition. | Meiners et al., 2019 (69) |
| Paroxetine (selective serotonin reuptake inhibitor [SSRI]) | Rats with collagen-induced arthritis (CIA) | The in vitro treatment of murine CD3+ T-cells with paroxetine (10–5 M) prevents Th17-cells differentiation under IL-6/TGF-β/IL-23 induction via GRK2 inhibition. The in vivo treatment of CIA rats with paroxetine (15 mg/kg/day) significantly reduced the splenic Th17-cells. | Hu et al., 2021 (70) |
| Fluoxetine (SSRI) | RRMS with depression | The treatment with fluoxetine (20 mg/day) during 6 months reduced the IL-17 production by Pam3C or LPS-activated CD4+ and CD8+ T-cells. | Sales et al., 2021 (49) |
| Fluoxetine | RRMS | Fluoxetine (10–6 M) suppresses IL-17, IFN-γ, and GM-CSF production by anti-CD3/CD28-activated CD4+ T-cells in RRMS patients and healthy subjects. 5-HT2B-receptor antagonist reduced the inhibitory effect of fluoxetine on cytokine production in MS patients. | Sviridova et al., 2021 (18) |