FIGURE 2.

C5 chromosome location and linkage disequilibrium (LD) plot of the selected missense mutations (A). Location of C5 on Chromosome 9q33.2. C5 consists of 1,682 amino acids and consists of 43 exons. Chromosome position (build GRCh38. p14) for the investigated SNPs rs17216529:C>T and rs17610:C>T. The alignment and gene structure for C5 was retrieved from dbSNP database (B). C5 genotype minor allele frequencies (MAF) from the HapMap database for Kenyan populations [Luhya (LWK), Maasai (MKK) and calculated by MIDAS for the Luo (current study). MAFs from the 1,000 Genome project shows the African (AFR) and global allele frequencies. MAFs for the current Luo (Kenyan) population are also presented (C). Linkage disequilibrium plot for rs17216529:C>T and rs17610:C>T SNPs (D’ = 0.581, LOD = 10.63, R ² = 0.02). The two SNPs are in linkage equilibrium, that is, they are inherited independently.