TABLE 2.
Number of malaria and SMA episodes, and all-cause mortality across the 36-months follow-up period stratified by genotype/haplotype.
| Genotype/Haplotype | Amino acid | Malaria episodes | SMA episodes | Mortality |
|---|---|---|---|---|
| rs17216529:C>T | Val151Ile | Total = 6,892 | Total = 382 | Total = 81 |
| CC | Val151Val | 3,245 | 173 | 40 |
| CT | Val151Ile | 2,644 | 140 | 33 |
| TT | Ile/Ile 151 | 1,003 (14.55) | 69 | 8 |
| χ2 goodness of fit test | χ2 = 78.754 | χ2 = 0.711 | χ2 = 2.562 | |
| p<0.001 | p = 0.701 | p = 0.278 | ||
| rs17610:C>T | Ser1310Asn | Total = 7,173 | Total = 405 | Total = 82 |
| CC | Ser1310Ser | 6,231 | 341 | 70 |
| CT | Ser1310Asn | 490 | 35 | 7 |
| TT | Asn1310Asn | 452 (6.30) | 29 | 5 |
| χ2goodness of fit test | χ2 = 17.981 | χ2 = 2.196 | χ2 = 0.704 | |
| p = 0.00012 | p = 0.334 | p = 0.703 | ||
| rs17216529:C>T/rs17610:C>T | Val151Ile/Ser1310Asn | Total = 7,758 | Total = 447 | Total = 99 |
| Non-CC | non-Val151Ser1310 | 1,596 | 113 | 16 |
| CC | Val151Ser1310 | 6,162 | 334 | 83 |
| Non-CT | non-Val151Asn1310 | 4,259 | 247 | 61 |
| CT | Val151Asn1310 | 3,499 | 200 | 38 |
| Non-TC | non-Ile151Ser1310 | 6,797 | 384 | 87 |
| TC | Ile151Ser1310 | 961 | 63 | 12 |
| Non-TT | non-Ile151Asn1310 | 7,604 | 437 | 96 |
| TT | Ile151Asn1310 | 154 | 10 | 3 |
Data are presented as numbers of malaria, SMA and mortality cases during the 36-months follow-up period. These were classified by the C5 genotypes and haplotypes. The summary statistics were performed using R (version 3.1.3).
Bold indicate significant p values.
Non-CC refers to non-wild genotypes for both SNPs, consistently non-CT is non-C in the first SNP and non-T in the second SNP.