Figure 5.

Role of tubular structures in macrophage trogocytosis

Fluorescence image acquired at 1020 s inside the 1.8 and 1.2 μm focal planes showing the Trastuzumab signal in cancer cells (red fluorescence) and displaying a trogocytic event (enlarged in the left panel) involving the formation of two tubular structures (orange arrows and white dashed line) engaging between a macrophage (green fluorescence) and a cancer cell. These tubular structures evolve with the invagination of the cancer cell membrane. Yellow arrows in the grayscale panels indicate intermediate architectures in the evolution of the tubular structure. Numbers at the bottom left of each black/white panel depict the acquisition time (seconds) for each frame. Scale bars = 5 μm (© Velmurugan et al., 2016; The American Association for Cancer Research).