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. 2022 Sep 14;13:975233. doi: 10.3389/fimmu.2022.975233

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Copyright © 2022 Falcon, Smith, Al-Obaidi, Abu Zaanona, Purvis, Minagawa, Athar, Salzman, Bhatia, Goldman and Di Stasi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) ΔiC8-RQR8 (Elafin1a promoter), Rapa.ΔiC9-ΔCD19 (Human-PGK promoter) lentiviral constructs, and proteins diagram; ΔiC8 and Rapa.ΔiC9 are activatable by the BB homodimerizer or sirolimus, respectively. (B) Average with SD of the percentage of killing in non-transduced Jurkat cells, or Jurkat cells gene-modified to express ΔiC8-RQR8, Rapa.ΔiC9-ΔCD19, or both (N: 3-7 experiments) after overnight exposure to the BB homodimerizer at 100nM, sirolimus (siro) 25 ng/mL or both.