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. 2022 Sep 14;13:975233. doi: 10.3389/fimmu.2022.975233

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Copyright © 2022 Falcon, Smith, Al-Obaidi, Abu Zaanona, Purvis, Minagawa, Athar, Salzman, Bhatia, Goldman and Di Stasi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Retroviral transgenic construct and protein diagram of ΔiC9-RQR8-GFP activatable with the BB homodimerizer and the anti-CD20 monoclonal antibody rituxan. 6(B) Dot-plots of QBend10/GFP expression from a representative experiment. (C) Summary of N: 3-5 killing experiments of Jurkat non-transduced, expressing the RQR8 compact suicide gene or the iC9 and the RQR8 suicide gene in a single construct treated with the BB homodimerizer overnight [100nM], or rituxan [100 ug/mL] for four hours in the presence of rabbit serum complement. (D). Dot-plot and fluorescent images from one representative killing assay.