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. 2022 Aug 29;11(3):250–261. doi: 10.12997/jla.2022.11.3.250

Fig. 2. The metabolism of TRLs and the role of apoCIII. Triglyceride-rich VLDL is released from the liver and converted to IDL by lipoprotein lipase (LPL). Chylomicrons are formed in the intestine and transformed into chylomicron remnants by LPL. ApoCIII regulates TRL metabolism by inhibiting the activity of LPL (LPL-dependent pathway) and by interfering with hepatic clearance of TRL remnants (LPL-independent pathway).

Fig. 2

TRL, triglyceride-rich lipoprotein; apoCIII, apolipoprotein CIII; VLDL, very low-density lipoprotein; IDL, intermediate-density lipoprotein; LPL, lipoprotein lipase; CETP, cholesteryl ester transfer protein.