Fig. 4. TG metabolism and the role of ANGPTL3. Dietary fat is transported through the blood as part of chylomicrons. TGs in the chylomicrons are hydrolyzed by LPL. The GPIHBP1 transports LPL from the cell surface to the capillary endothelium. ANGPTL3, produced in the liver and secreted into the circulation, inhibits LPL in peripheral tissues. The function of ANGPTL3 as an LPL inhibitor is dependent on ANGPTL8, which is also produced in the liver and forms a complex with ANGPTL3.
TG, triglyceride; ANGPTL3, angiopoietin-like protein 3; ANGPTL8, angiopoietin-like protein 8; LPL, lipoprotein lipase; GPIHBP1, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1.