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. 2022 Sep 14;13:912579. doi: 10.3389/fimmu.2022.912579

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Copyright © 2022 Ceperuelo-Mallafré, Reverté, Peraire, Madeira, Maymó-Masip, López-Dupla, Gutierrez-Valencia, Ruiz-Mateos, Buzón, Jorba, Vendrell, Auguet, Olona, Vidal, Rull and Fernández-Veledo

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Study design and patient cohort distribution. Cohort 1 comprised 273 patients consecutively recruited during the first COVID-19 wave (March-May 2020) from the outpatient clinics of the participating hospitals. Cohort 2 included 398 patients with COVID-19 recruited from March 2020 to December 2020 at the HUJ23. Patients were stratified by disease severity. Serum samples were used for semi-targeted metabolomic analysis (cohort 1) and quantitative fluorimetric assays (cohort 2).