Figure 3.

Energy-related metabolites in the validation cohort. (A) Serum levels (µM) of succinate, lactate, pyruvate and α-ketoglutarate determined by fluorimetric assay in patients with mild (n=65), severe (n=218) and critical (n=115) COVID-19 disease. Statistical significance was estimated using the Kruskal-Wallis test and Dunn’s multiple comparisons test. (B) Receiver operating characteristic curves predicting COVID-19 severity included the parameters of the regression model (Table 3). (C) Regression tree (CART) analysis including all the previously selected variables as predictors of COVID-19 severity. The results were considered significant at *P<0.05; **P<0.01; ***P<0.001.