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. 2022 Sep 14;13:912579. doi: 10.3389/fimmu.2022.912579

Table 1.

Patient characteristics of COVID-19 cohort 1.

COVID-19
Variables Mild (n = 77) Severe (n = 134) Critical (n = 62) P value
Gender (male) 26 (33.8) 74 (55.2) 42 (67.7) n.s.
Age (years) 41.0 (28.0-53.0) 64.0 (49.8-75.0) 65.0 (53.0-74.25) <0.0001
COVID-19-Mortality 0 (0) 11 (8.2) 17 (27.4) <0.0001
Comorbidities
 Obesity 6 (7.8) 23 (17.2) 12 (19.4) <0.0001
 Metabolic syndrome 0 (0) 9 (6.7) 8 (12.9) <0.0001
 Diabetes mellitus 2 (2.6) 24 (17.9) 18 (29.0) <0.0001
 Hypertension 7 (9.1) 60 (44.8) 30 (48.4) <0.0001
 Cardiovascular disease 4 (5.2) 31 (23.1) 6 (9.7) <0.0001
Inflammatory cytokines
 IL-7 (pg/mL) 5.3 (1.6-10.1) 8.1 (3.4-11.8) 9.7 (4.6-20.4) 0.007
 IL-15 (pg/mL) 6.7 (4.0-8.7) 10.9 (6.3-18.6) 15.1 (8.9-23.6) 0.001
 TNF-α (pg/mL) 33.2 (18.1-60.0) 48.5 (34.3-81.7) 65.5 (53.7-87.8) 0.040
 IFN-γ (pg/mL) 9.2 (4.1-16.5) 13.6 (4.9-24.0) 10.7 (5.4-23.6) n.s.
Biochemical parameters
 D-Dimer 130.5 (99.3-198.5) 676.0 (398.0-1088.0) 752.0 (543.5-1394.5) <0.0001
 Fibrinogen 358.3 (430.5-521.5) 712.5 (563.8-826.0) 779.5 (640.0-923.5) <0.0001
 IL-6 12.8 (2.5-34.2) 13.6 (5.7-30.1) 29.2 (8.4-93.0) n.s.
 Ferritin 198.5 (84.0-502.8) 439.0 (172.0-1486.5) 770.0 (238.0-1571.0) <0.0001
 CRP 0.55 (0.1-3.8) 17.0 (6.1-53.1) 12.6 (5.6-17.7) <0.0001
 Glucose 91 (81.5-104.5) 110.0 (98.0-128.8) 118.0 (102.0-134.8) <0.0001

Data are presented as n (%) and median (25th and 75th interquartile range) for qualitative and quantitative variables, respectively. IL, interleukin; TNF-α, tumor necrosis factor alpha; IFN- γ, interferon gamma; CRP, C-reactive protein. n.s., non-significant.