Table 1.
Patient characteristics of COVID-19 cohort 1.
| COVID-19 | ||||
|---|---|---|---|---|
| Variables | Mild (n = 77) | Severe (n = 134) | Critical (n = 62) | P value |
| Gender (male) | 26 (33.8) | 74 (55.2) | 42 (67.7) | n.s. |
| Age (years) | 41.0 (28.0-53.0) | 64.0 (49.8-75.0) | 65.0 (53.0-74.25) | <0.0001 |
| COVID-19-Mortality | 0 (0) | 11 (8.2) | 17 (27.4) | <0.0001 |
| Comorbidities | ||||
| Obesity | 6 (7.8) | 23 (17.2) | 12 (19.4) | <0.0001 |
| Metabolic syndrome | 0 (0) | 9 (6.7) | 8 (12.9) | <0.0001 |
| Diabetes mellitus | 2 (2.6) | 24 (17.9) | 18 (29.0) | <0.0001 |
| Hypertension | 7 (9.1) | 60 (44.8) | 30 (48.4) | <0.0001 |
| Cardiovascular disease | 4 (5.2) | 31 (23.1) | 6 (9.7) | <0.0001 |
| Inflammatory cytokines | ||||
| IL-7 (pg/mL) | 5.3 (1.6-10.1) | 8.1 (3.4-11.8) | 9.7 (4.6-20.4) | 0.007 |
| IL-15 (pg/mL) | 6.7 (4.0-8.7) | 10.9 (6.3-18.6) | 15.1 (8.9-23.6) | 0.001 |
| TNF-α (pg/mL) | 33.2 (18.1-60.0) | 48.5 (34.3-81.7) | 65.5 (53.7-87.8) | 0.040 |
| IFN-γ (pg/mL) | 9.2 (4.1-16.5) | 13.6 (4.9-24.0) | 10.7 (5.4-23.6) | n.s. |
| Biochemical parameters | ||||
| D-Dimer | 130.5 (99.3-198.5) | 676.0 (398.0-1088.0) | 752.0 (543.5-1394.5) | <0.0001 |
| Fibrinogen | 358.3 (430.5-521.5) | 712.5 (563.8-826.0) | 779.5 (640.0-923.5) | <0.0001 |
| IL-6 | 12.8 (2.5-34.2) | 13.6 (5.7-30.1) | 29.2 (8.4-93.0) | n.s. |
| Ferritin | 198.5 (84.0-502.8) | 439.0 (172.0-1486.5) | 770.0 (238.0-1571.0) | <0.0001 |
| CRP | 0.55 (0.1-3.8) | 17.0 (6.1-53.1) | 12.6 (5.6-17.7) | <0.0001 |
| Glucose | 91 (81.5-104.5) | 110.0 (98.0-128.8) | 118.0 (102.0-134.8) | <0.0001 |
Data are presented as n (%) and median (25th and 75th interquartile range) for qualitative and quantitative variables, respectively. IL, interleukin; TNF-α, tumor necrosis factor alpha; IFN- γ, interferon gamma; CRP, C-reactive protein. n.s., non-significant.